Voriconazole is a triazole antifungal medication used to treat serious fungal infections.
Vori is an azole antifungal medicine. It is indicated for use in patients 12 years of age and older in the treatment of following fungal infections-
Voriconazole is a triazole antifungal medication used to treat serious fungal infections. Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.
CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers: Adjust Vori dosage and monitor for adverse reactions or lack of efficacyVori may increase the concentrations and activity of drugs that are CYP3A4, CYP2C9 and CYP2C19 substrates. Reduce doses of these other drugs and monitor for adverse reactionsIncrease maintenance oral and intravenous dosage of Vori with co-administration of Phenytoin or Efavirenz
Known hypersensitivity to Voriconazole or any other components of this drug-Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactionsCo-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids and St. John's Wort due to risk of loss of efficacy
The most common side effects are abdominal pain, anemia, blurred vision, headache, chest pain, nausea and diarrhea.
There are no adequate and well-controlled studies in pregnant woman. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Long term exposure (treatment or prophylaxis) greater than 180 days requires careful assessment of the benefit-risk balance. Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term Vori treatment.
The efficacy to the children under 12 years of age is not established.
There is no data found about overdose of Vori.
Other Antifungal preparations
Reconstitution Instructions of suspension: Shake the bottle well before adding water to loosen the powder. Add 25 ml of boiled and cooled water to the bottle (5 spoons of a provided spoon). Shake the closed bottle vigorously until powder mixed completely with the water. Store reconstituted suspension between 15°-30° C. Discard suspension 14 days after reconstitution.
Keep out of reach of children. Store in a dry place, below 25°C temperature and protected from light. Store Vori powder for suspension between 2° to 8°C temperature.
