Suvotol is indicated for the treatment of insomnia, characterized by difculties with sleep onset and/or sleep maintenance.
Suvotol is indicated for the treatment of insomnia, characterized by difculties with sleep onset and/or sleep maintenance.
Suvorexant is a highly selective antagonist for orexin receptors OX1R and OX2R. The mechanism by which Suvorexant exerts its therapeutic efect in insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.
Recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily. Lowest dose effective should be used for the patient. Time to effect may be delayed if taken with or soon after a meal.
CNS-Active Drugs: An additive effect on psychomotor performance was observed when a single dose of 40 mg of Suvotol was co-administered with a single dose of 0.7 g/kg alcohol. Suvotol does not afect alcohol concentrations and alcohol does not afect Suvotol concentrations.
Do not use in patients with narcolepsy.
Common side effects are Sleepiness during the day, Not thinking clearly, Act strangely, confused, or upset, Sleep-walking
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Suvorexant should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether this drug is secreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Suvorexant is administered to a nursing woman.
Miscellaneous sedatives & hypnotics
Store in dry and cool place, protect from light & keep away from children.
