Vono 20mg Tablet

Vonoprazan is a potassium competitive acid blocker (P-CAB) and does not require activation by acid.

Indications

Vono is indicated for:

•  Gastric ulcer, duodenal ulcer, reflux esophagitis, prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration, prevention of recurrence of gastric or duodenal ulcer during NSAID administration.
• Adjunct to Helicobacter pylori eradication in the following: Gastric ulcer, duodenal ulcer, gastric mucosa-associated lymphatic tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, the stomach after endoscopic resection of early-stage gastric cancer or Helicobacter pylori gastritis.

Pharmacology

Vonoprazan is a potassium competitive acid blocker (P-CAB) and does not require activation by acid. It inhibits H+, K+-ATPase in a reversible and potassium-competitive manner. Vonoprazan has a strong basicity and resides on the acid production site of gastric parietal cells for a long time, thereby inhibiting gastric acid production. Vonoprazan exerts a strong inhibitory effect on formation of mucosal damage in upper part of the gastrointestinal tract.

Administration

Vonoprazan can be taken without regard to food or timing of food.

Contraindications

Vonoprazan is contraindicated in:Patients with hypersensitivity to Vonoprazan or to any excipient of the product.Patients receiving atazanavir sulphate, nelfinavir or rilpivirine hydrochloride.

Side Effects

Following side effects have been reported with the use of Vono: Diarrhea, constipation, drug hypersensitivity (including anaphylactic shock), drug eruption, urticaria, hepatotoxicity, jaundice, rash, nausea, abdominal distension, gamma-glutamyl transferase increased, AST increased, Liver function test abnormal, ALT increased, ALP increased, LDH increased, y-GPT increased, edema and eosinophilia

Pregnancy & Lactation

Vonoprazan should be used in pregnant women or women having possibility of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk. It is advisable to avoid the administration of Vonoprazan to nursing mothers. However, when the administration is indispensable, nursing should be discontinued.

Overdose Effects

There is no experience of overdose with Vono. Vono is not removed from the circulation by hemodialysis. If overdose occurs, treatment should be symptomatic and supportive.

Therapeutic Class

Potassium competitive acid blocker

Storage Conditions

Store below 30°C, in a cool and dry place. Keep away from light. Keep all the medicine out of the reach of children.