Urso is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones.
Urso is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones.
Urso is indicated for the treatment of-
Urso is used to reduce the cholesterol saturation of bile and to promote the dissolution of gallstones. The cholesterol saturation of bile is reduced by Urso, allowing gradual solubilization of cholesterol gallstones. Cholesterol of secretion into bile is reduced and bile acid secretion rate is increased during Urso treatment without a reduction in phospholipids.
Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided doses.
Primary Billiary Cirrhosis: 10-15 mg/kg/day in 2-4 divided doses.
Acute Viral Hepatitis: 600 mg/day.
Alcoholic Fatty Liver: 300 mg/day.
Primary Sclerosing Cholangitis: 25-30 mg/kg/day.
Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day.
Urso should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Urso.
Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.
Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.
It should be used cautiously in those with liver disease.
Anti-gallstones drugs: Bile Acids
Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.
