Pharmacology
The USP refers to Coenzyme Q10 as Ubidecarenone which is a fat-soluble vitamin like substance. It is presented in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production.
Statins: The statin drugs reduce endogenous synthesis of Ubidecarenone in the body. Thus, Ubidecarenone supplement may increase Ubidecarenone levels without adversely affecting statin drug's efficacy.
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta blockers (particularly propanolol) have been reported to inhibit some Ubidecarenone dependent enzymes,
Antidiabetic medications: May improve glycemic control in some type II diabetics. If this occurred, antidiabetic medications may need appropriate dose adjustment.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin।
Co-enzyme Q10 is contraindicated in patients who have hypersensitivity to the active substance or to any of the excipients. It is also contraindicated in patients scheduled for surgery in the next two weeks.
Co-enzyme Q10 is safe for most adults. It can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people.
Co-enzyme Q10 should not be used in pregnancy and breast-feeding.
Co-enzyme Q10 may lower blood sugar levels, so caution should be taken in patients with diabetes or hypoglycemia. Co-enzyme Q10 may decrease blood pressure so caution is advised in patients with low blood pressure or taking blood pressure medications.
Herbal and Nutraceuticals, Supplements & adjuvant therapy
Keep in a dry place away from light and heat. Keep out of the reach of children.