Renolog Tablet 600mg

 Renolog tablet is indicated for prevention & treatment of damages due to faulty or deficient protein metabolism in chronic kidney disease in connection with a limited dietary protein intake 40 gm/day or less(adult). Usually this applies to patients whose glomerular filtration rate (GFR) is less than 25 ml/min.

Pharmacology

This nutritional supplement contains amino acids, partly in form of there corresponding ketoanalogues, essential for patients with chronic kidney disease. It follows same catabolic pathways as amino acids and works by improving the metabolism of protein in the body, thereby improving the renal function.

Dosage & Administration

• In general, unless prescribed otherwise, take 4-8 tablets 3 times a day during meals. This dosage applies to adults (with 70 kg body weight).
• Swallow whole. The tablets must not be chewed. Food should contain 40 g/day protein or less (adults).
• Ingestion during meals facilitates proper absorption and the metabolisation into the corresponding amino acids.
• These tablets are given as long as the GFR is between 5 and about 25mL/minute.

Interaction

• Concomitant administration of calcium-containing drugs may cause or aggravate elevated serum calcium levels.
• In case of aluminum hydroxide administration, the dose of Renolog has to be reduced if necessary.
• Drugs that form hardly soluble compounds with calcium (e.g., tetracyclines, quinolones such as 

Contraindications

Hypersensitivity to the active substances or to any of the excipients, Hypercalcemia,

Side Effects

Hypercalcaemia (Very Rare), If hypercalcaemia occurs, the intake of vitamin D should be reduced. In case of persisting hypercalcaemia, the dose of Renolog Acid Keto Analogues as well as the intake of any other calcium sources has to be reduced.

Pregnancy & Lactation

There are no adequate data from the use of Amino Acid Keto Analogues in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/fetal development, parturition or postnatal development.

Precautions & Warnings

• The serum calcium level should be monitored regularly
• Ensure sufficient calorie intake
• In the presence of hereditary phenylketonuria, attention should be given to the fact that Renolog Acid Keto Analogues contains phenylalanine
• Monitoring of the serum phosphate levels is needed in case of concomitant administration of aluminium hydroxide