Radimet 850mg Tablet

Indications Radimet tablet is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight patients when dietary management and exercise alone does not result in adequate glycaemic control.

In adults: Radimet may be used as monotherapy or in combination with other oral antidiabetic agents or with insulin.

In children from 10 years of age and adolescents: Radimet may be used as monotherapy or in combination with insulin.

Pharmacology

Metformin is a biguanide type oral antihyperglycemic drug used in the management of type 2 diabetes. It lowers both basal and postprandial plasma glucose.

Dosage & Administration

Metformin immediate release tablet: Dosage of Metformin Hydrochloride must be individualized on the basis of both effectiveness and tolerance, while not exceeding the maximum recommended daily doses

Interaction 

No information is available about the interaction of Radimet and Furosemide when co-administered chronically. Nifedipine appears to enhance the absorption of Radimet. Radimet had minimal effects on Nifedipine.

Contraindications

• Hypersensitivity to the active substance or to any of the excipients.
• Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
• Severe renal failure (GFR <30 mL/min).
• Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock.
• Acute or chronic disease, which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock, Hepatic insufciency, acute alcohol intoxication, alcoholism.

Side Effects

Blood and lymphatic system disorders: Not known: Hemolytic anemia Metabolism and nutrition disorders: Very rare: Lactic acidosis. Decrease of vitamin B12 absorption with a decrease of serum levels during long-term use of metformin. Consideration of such etiology is recommended if a patient presents with megaloblastic anemia.

Precautions & Warnings

Radimet is known to be substantially excreted by the kidney and the risk of Radimet accumulation and lactic acidosis increases with the degree of impairment of renal function. Radimet may lower vitamin B12 level. It also increases risk of hypoglycemia when use in combination with insulin or insulin secretagogue.

Overdose Effects

Hypoglycemia has not been seen with Radimet doses up to 85 gm, although lactic acidosis has occurred in such circumstances. Lactic acidosis is a medical emergency and must be treated in hospital. The most effective method to remove lactate and Radimet is hemodialysis.

Therapeutic Class

Biguanides

Storage Conditions

Keep below 30°C temperature, protected from light & moisture. Keep out of the reach of children.