Prelizer-HTZ drug may potentiate the action of other antihypertensive agents used concomitantly. Prelizer-HTZ drug should not be combined with other beta-blocking agents.
Bisoprolol Fumarate and Hydrochlorothiazide have been used individually and in combination for the treatment of hypertension. The antihypertensive effects of these agents are additive; Hydrochlorothiazide 6.25 mg significantly increases the antihypertensive effect of Bisoprolol Fumarate.
Prelizer-HTZ tablet is indicated in the treatment of Hypertension.
Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 to 40 mg, while Hydrochlorothiazide is effective in doses of 12.5 to 50 mg.
Prelizer-HTZ drug may potentiate the action of other antihypertensive agents used concomitantly. Prelizer-HTZ drug should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored because the added beta-adrenergic blocking action of Bisoprolol Fumarate may produce excessive reduction of sympathetic activity.
It is contraindicated in patients in cardiogenic shock, overt cardiac failure, second or third degree AV block, marked sinus bradycardia, anuria and hypersensitivity to either component of this product or to other sulfonamide-derived drugs.
Generally well tolerated. Most side effects have been mild and transient. Side effects which may occur: fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbances, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis etc.
Use in Pregnancy: Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Bisoprolol Fumarate and Hydrochlorothiazide should be used during pregnancy only if the potential benefit justifies the risk to the fetus.
Hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics.
Overdose Effects There are limited data on overdose with Prelizer-HTZ product. The most frequently observed signs expected with overdosage of a beta-blocker are bradycardia and hypotension.
Combined antihypertensive preparations
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
