Paloset 0.5mg Tablet

Paloset indicated in-

• Acute and delayed nausea and vomiting
• Uncontrolled nausea and vomiting
• Chemotherapy-induced nausea and vomiting (CINV): Acute CINV resulting in on the day of treatment with certain types of chemotherapy
• Delayed CINV resulting in on days later with certain types of chemotherapy
• Radiotherapy-induced nausea and vomiting (RINV)
• Post-operative & Post-discharge nausea and vomiting (PONV & PDNV).

Interaction

In controlled clinical trials, Paloset injection has been safely administered with corticosteroids, analgesics, antiemetics/antinauseants, antispasmodics and anticholinergic agents.

Contraindications

Palonosetron is contraindicated in patients known to have hypersensitivity to the drug or any of its components.

Side Effects

The most common adverse reactions are headaches and constipation.

Pregnancy & Lactation

Pregnancy category 'B'. It is not known whether Palonosetron is excreted in breast milk.

Use in Special Populations

Use in elderly patients: No dosage adjustment is recommended in elderly patients >65 years of age.Use in Children: (1 month to 10 years): A single IV dose at 20 mcg/kg body weight. Which maximum dose is 1.5 mg.Use in patients with impaired renal and hepatic function: No dosage adjustment is recommended in patients with renal and hepatic dysfunction.

Overdose Effects

There is no known antidote to Paloset. Overdose should be managed with supportive care.

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Store in a cool & dry place, protected from light.