Ceftibuten is the dihydrate salt of Ceftibuten, is a semi-synthetic Cephalosporin antibiotic for oral administration.
Ceftibuten is the dihydrate salt of Ceftibuten, is a semi-synthetic Cephalosporin antibiotic for oral administration.
Ceftiben is indicated for the treatment of individuals with mild-to-moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Acute Bacterial Exacerbations of Chronic Bronchitis: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including (β-lactamase producing strains), or Streptococcus pneumoniae (penicillin-susceptible strains only).
Acute Bacterial Otitis Media: Due to Haemophilus influenzae (including β-lactamase producing strains), Moraxella catarrhalis (including β-lactamase producing strains) or Streptococcus pyogenes
Ceftibuten is the dihydrate salt of Ceftibuten, is a semi-synthetic Cephalosporin antibiotic for oral administration. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis..
Theophylline & Antacid do not alter the pharmacokinetic profile of Ceftiben. Ranitidine increases the Cmax & AUC of Ceftiben.
Ceftibuten is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Nausea, headache, diarrhea, dyspepsia, dizziness, abdominal pain, vomiting.
Pregnancy Category B. There are no controlled data on the use of Ceftibuten in pregnant women. Ceftibuten should be used in pregnancy only when the benefit clearly outweighs the risk. It is not known whether Ceftibuten (recommended dosage) is excreted in human milk. Because many drugs are excreted in human milk, caution should be excercised when Ceftibuten is administered to nursing women.
As with other broad-spectrum antibiotics, prolonged treatment may result in the possible emergence and overgrowth of resistant organisms. Careful observation of the patient is essential. The dose of Ceftiben may require adjustment in patients with varying degrees of renal insufficiency. Ceftiben should be prescribed with caution to individuals with a history of gastrointestinal disease, particularly colitis.
Renal Impairment-CrCl 5 to 29 ml/min: 2.25 mg/kg or 100 mg orally once a dayCrCl 30 to 49 ml/min: 4.5 mg/kg or 200 mg orally once a dayHepatic Impairment: Dose adjustment is not necessary.
Third generation Cephalosporins
The small bottle contains purified water and large bottle contains granulesPour the purified water completely into large bottle Tighten the cap of large bottle and shake the bottle for at least one minuteUse a measuring cup or dropper for reconstituted suspensionPrepared suspension to be consumed within 14 days of preparation if kept in a refrigerator. Shake the bottle well each time before use.
Store below 25°C, protected from light and moisture. For Suspension: After reconstitution, the suspension may be used for 14 days while stored at 2° to 8°C. Keep out of reach of children.
