Aripiprazole is an atypical antipsychotic that has both dopamine and serotonin receptors activity.
Indications
Ariprex is indicated for-
Aripiprazole is an atypical antipsychotic and it has been proposed that the efficacy of Aripiprazole is mediated through a combination of partial agonist activity at Dopamine D2 and Serotonin 5-HT 1A receptors and antagonist activity at Serotonin 5-HT 2A receptors. This is associated with improvement of schizophrenia, bipolar disorder, major depressive disorder, irritability associated with autistic disorder, and agitation associated with schizophrenia or bipolar disorder.
Oral formulations: Administer once daily without regard to meals.
IM injection: Wait at least 2 hours between doses. Maximum daily dose 30 mg.
Caution should be exercised when Ariprex is taken in combination with other centrally acting drugs and alcohol. Carbamazepine could cause an increase in Ariprex clearance and lower blood levels. Ketoconazole, quinidine, fluoxetine or paroxetine can inhibit Ariprex elimination and cause increased blood levels.
Known hypersensitivity to Aripiprazole.
Vomiting, nausea, akathisia, extrapyramidal disorder, somnolence, sedation, dizziness, insomnia, tremor, restlessness, fatigue, blurred vision, salivary hypersecretion, constipation, pyrexia, drooling, decreased appetite.
Pregnancy category C. It should be avoided during pregnancy. It is recommended that women receiving Aripiprazole should not breast-feed.
Ariprex at doses up to 1080 mg causes no fatalities. The signs and symptoms observed with Ariprex overdose included nausea, vomiting, asthenia, diarrhea, and somnolence.
Atypical neuroleptic drugs
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
