Tramadol is a centrally acting synthetic analgesic compound.
Anadol is used for the treatment of moderate to severe painful conditions. These include:
Tramadol is a centrally acting synthetic analgesic compound. It inhibits the re uptake of neurotransmitters- serotonin and noradrenaline. Thus it modifies the transmission of pain impulses by activating both descending serotonergic pathways and noradrenergic pathways involved in analgesia. The analgesic effects of Tramadol are mediated via stimulation of mu-opioid receptors and indirect modulation of central monoaminergic inhibitory pathways.
In general, physician need not be concerned about drugs interacting with Anadol. The monoamine oxidase (MAO) inhibitors represent the only drug class not recommended for combination with Anadol. Concomitant administration of carbamazepine with Anadol causes a significant increase in Anadol metabolism and it requires to increase the dose of Anadol.
Tramadol is contraindicated in persons having hypersensitivity to this drug. It is also contraindicated in acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic drugs.
Commonly occurring side-effects are dizziness/vertigo, nausea, constipation, headache, somnolence, vomiting, pruritus, CNS stimulation, asthenia, sweating, dyspepsia, dry mouth, diarrhoea. Less commonly occurring side-effects include malaise, allergic reaction, weight loss, vasodilatation, palpitations, abdominal pain, anorexia, flatulence, GI bleeding, hepatitis, stomatitis etc.
Safe use of Tramadol in pregnancy has not been established. Tramadol has been shown to cross the placenta. There are no adequate and well-controlled studies in pregnant women. Therefore, Tramadol should be used during pregnancy only if the potential benefit justifies the risk to the foetus. Tramadol Hydrochloride should not be administered during breast feeding as Tramadol and its metabolites have been detected in breast milk.
In children from the age of 1 year Anadol can be given in a dose of 1-2 mg/kg body weight. However,suppository (100 mg Anadol) should not be administered in children and adolescents below the age of 14 years. Anadol 100 mg SR Capsules have not been studied in children. Therefore, safety and efficacy have not been established and the product should not be used in children.
Opioid analgesics
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
