Calamine is an itch medicine that creates a cooling sensation as it evaporates on the skin. It can also dry oozing or weeping from minor irritation due to poison ivy, poison oak, or poison sumac. Temporary relief of pain and itching associated with insect bites, poison oak, ivy, or sumac and minor skin irritations, bug bites, or rashes. It can treat diaper rashes in babies, soothe dry skin, and treat insect bites and chicken pox blisters. It has also been known to aid in the treatment of minor skin irritations like psoriasis, eczema, and hives.